305_314

Psychiatr. Pol. 2015; 49(2): 305–314

DOI: http://dx.doi.org/10.12740/PP/28048

Agnieszka Kałwa, Bogusław Habrat

FREE POLISH FULLTEXT:
Zaburzenia funkcji poznawczych spowodowane nadmierną ekspozycją na związki manganu. Zaburzenia funkcji poznawczych u dożylnych użytkowników preparatów efedronu (metkatynonu)

FREE ENGLISH FULLTEXT:
Cognitive dysfunctions caused by excessive exposure to manganese compounds. Cognitive disturbances in intravenous usersof ephedrone (methcathinone) with manganese compounds

Summary
Intravenous injection of self-produced ephedrone (metcathinone) using potassium permanganate as an oxidant can lead to severe, fixed encephalopathy. This risk applies mainly to young individuals experimenting with “home-made” drugs and results in an irreversible aggravation of overall functioning. Besides multiple neurological symptoms and movement disorders, affected individuals also experience cognitive dysfunction. No systematic research has been conducted in this field. Single case reports and small group descriptions show that assessment with screening tools such as the Mini-Mental State Examination (MMSE) is ineffective. Neuropsychological assessment conducted with other tests indicates significant
dysarthric speech disorders, psychomotor function impairment, attentional disorders of varying intensity as well as dysfunctions of verbal and visual working memory processes. Some studies of this group of subjects also indicate working memory and executive function disorders. These dysfunctions seem to be permanent and do not recede following manganese use discontinuation and an improvement of the neuroradiological picture in MRI assessment. A standard test battery should be developed enabling the assessment of both cognitive and neurological dysfunctions that otherwise render some tests impossible to administer.



ISSN 0033-2674 (PRINT)

ISSN 2391-5854 (ONLINE)


Psychiatria Polska
is an Open Access journal:
Creative Commons: CC-BY
SHERPA RoMEO:
Blue





Inne strony PTP:
Other PTP websites:

www.psychiatria.org.pl
www.psychiatriapsychoterapia.pl

www.archivespp.pl
www.psychoterapiaptp.pl

Psychiatria Polska
INDEXED IN:
Thomson Reuters Master List
Science Citation Index Expanded
Journal Citation Reports
(Impact Factor 1,010)

Medline/Index Medicus
MNiSW (15 pkt)
Scopus/SCImago
EMBASE/Excerpta Medica
PsycINFO, EBSCO, DOAJ
Index Copernicus (18.59)
Erih Plus, Cochrane Library
CrossRef/DOI

We recommend:

Pharmacological Reports



+48  518-330-994
kontakt z Biurem KRW PTP