Psychiatr. Pol. 2015; 49(3): 455-464

DOI: http://dx.doi.org/10.12740/PP/33179

Alina Wilkowska, Michał Pikuła, Andrzej Rynkiewicz,
Joanna Wdowczyk-Szulc, Piotr Trzonkowski, Jerzy Landowski

Wzrost stężenia cytokin prozapalnych w osoczu pacjentów po zawale mięśnia sercowego a obecność depresji w okresie następnych 6 miesięcy

Increased plasma pro-inflammatory cytokine concentrations after myocardial infarction and the presence of depression during next 6-months

Introduction. The connection between myocardial infarction (MI) and depression has been studied for more than 20 years and it is clear now that the consequences of this comorbidity are serious and cannot be ignored. One of the mechanisms underlying this connection is the role of inflammatory reaction and autoimmune processes present in MI and depression. Aim. The aim of this study was to investigate plasma concentrations of four pro-inflammatory cytokines (IL17a, IL6, TNF. and IL12p70) in patients with myocardial infarction and to analyse them according to presence of depression observed during first 6 months after myocardial infarction.
Method. In 44 patients with the first acute STEMI (ST segment elevation myocardial infarction) plasma levels of IL17a, IL6, TNF. and IL12p70 were measured on the 3rd and 5th day after the MI. Cytokine concentrations were analyzed according to the presence of depression during 6 months of observation.
Results. Two groups of patients distinguished according to presence of depression during 6 months of observation differed in their inflammatory reaction to MI. In the depression group all four cytokines on the 3rd day after the MI were elevated compared to control and on the 5th day two of them: IL17a and IL6 were still elevated. In the group without depression on the 3rd day only two of four investigated cytokines were elevated and on the 5th day only IL6 concentration remained higher.
Conclusions. It can be assumed that more pronounced inflammatory response as an element of stress reaction after MI can predispose to depression. IL17a increase can play particularly important role in this process.

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