strona główna
mapa strony
kontakt
__997_1002
Psychiatr. Pol. 2019; 53(5): 997–1002
Mirosław Kowalski, Piotr Świtaj
FREE POLISH FULLTEXT:
FREE ENGLISH FULLTEXT:
Summary
Clozapine, atypical antipsychotic drug, is widely used in patients with schizophrenia, for whom previous therapy was inadequate or not tolerated. Clozapine-induced myocarditis (CIM) is a relatively rare but potentially life-threatening complication of clozapine therapy; however, the underlying mechanism has not been so far well elucidated. Factors predisposing to CIM include a rapid dose titration, advanced age and co-administration of sodium valproate. In this paper, we present a case of a 22-year-old male patient with refractory schizophrenia who developed CIMduring low-dose clozapine treatment with co-administration of valproate and risperidone. On the basis of our case and literature review, we point out that during the first weeks of clozapine treatment patients should be actively, daily monitored for the presence of symptoms suggesting CIM. The low dose of clozapine and concurrent use of valproate are unique aspects of the report, adding new information to the discussion on safety of concomitant use of clozapine and valproate. Further investigation is required to better understand the role of co-administration of valproate and risperidone in the pathogenesis of CIM.
ISSN 0033-2674 (PRINT)
ISSN 2391-5854 (ONLINE)
Psychiatria Polska
is an Open Access journal:
Creative Commons: CC-BY
SHERPA RoMEO: Blue
is an Open Access journal:
Creative Commons: CC-BY
SHERPA RoMEO: Blue
Zadanie finansowane
w ramach umowy
nr 739/P-DUN/2018
ze środków MNiSW
przeznaczonych
na działalność
upowszechniającą naukę
Inne strony PTP:
Other PTP websites:
www.psychiatria.org.pl
www.psychiatriapsychoterapia.pl
www.archivespp.pl
www.psychoterapiaptp.pl
Psychiatria Polska
INDEXED IN:
Thomson Reuters Master List
Science Citation Index Expanded
Journal Citation Reports
(Impact Factor 1,311)
Medline/Index Medicus
PubMed/LinkOut
MNiSW (40 pkt)
Scopus/SCImago
(SJR 0,345; H index 18 pkt)
EMBASE/Excerpta Medica
PsycINFO, EBSCO,
Index Copernicus (159 pkt)
Erih Plus, Cochrane Library
CrossRef/DOI
We recommend:
Pharmacological Reports