Online First Nr268

Psychiatr. Pol. ONLINE FIRST Nr 268: 1–20
 
Published ahead of print 25 February 2022
 
 
Joanna Rog, Karolina Skonieczna-Żydecka, Dariusz Juchnowicz,
Olga Padała, Igor Łoniewski, Barbara Budzyńska,
Hanna Karakula-Juchnowicz

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Summary
The aim of this systematic review was to determine: (1) differences between patients with AN and healthy controls (HC) in terms of gut microbiota community and intestinal barrier related markers; (2) relationship between the intestinal ecosystem and health-related factors in AN individuals. We conducted a systematic literature search (PubMed, Embase, Clinical-Trials registry) until 30 September 2020 for studies reporting gut microbiome and intestinal barrier-related markers in patients with AN. Six studies on intestinal microbiota were eligible for this review, including three papers also describing intestinal barrier markers. Among five studies analyzing microbiota diversity, four of them found differences between AN patients and healthy controls (HC). The studies confirm alterations of the markers of the intestinal barrier integrity in patients with anorexia. The systematic review confirms changes in the gut ecosystem of patients with eating disorder, without a clear consensus of microbiota patterns in AN. Damage of intestinal barrier integrity is poorly documented in AN patients and needs more attention in further studies.

ISSN 0033-2674 (PRINT)

ISSN 2391-5854 (ONLINE)


Psychiatria Polska
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