Online First Nr37

Psychiatr. Pol. ONLINE FIRST Nr 37
Published ahead of print 25 January, 2016
DOI: http://dx.doi.org/10.12740/PP/OnlineFirst/61131

Izabela Dymon, Justyna Tabaka-Pradela,
Katarzyna Knast, Dominika Dudek, Monika Rudzińska

FREE POLISH FULLTEXT:
Objawy neurologiczne i neuropsychologiczne w przewlekłej postaci choroby Whipple’a – opis przypadku

FREE ENGLISH FULLTEXT:
Neurological and neuropsychological complications in the course of chronic Whipple’s disease - case report

Summary
Introduction. Whipple’s disease (WD) is a chronic, multisystemic infectious disease caused by Gram-positive bacillus Tropheryma whipplei (T.w.). Its common symptoms arise in the digestive system, however, during the infection the CNS (Central Nervous System) may also be affected.
Aim. The aim of this work is to present a case report of a patient diagnosed with Whipple’s disease with dominant neuropsychological and behavioural complications in the late phase.
Conclusions. Whipple’s disease is a rare disease with possible neurological and neuropsychiatric complications. Neurological disorders (eye movement disorders, myoclonus, oculoskeletal myorhythia, progressive dementia) may develop in spite of correct pharmacological treatment. Apart from its classical symptoms, unspecified cognitive function disorders and autonomic nervous system disorders may develop. Providing right antibiotic treatment may not always lead to complete remission or prevent neuropsychiatric complications. However, early diagnosis and clinical alertness allow to administer right treatment and improve further prognosis.


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