Online First Nr44

Psychiatr. Pol. ONLINE FIRST Nr 44
Published ahead of print 27 June, 2016


Ludmiła Zając-Lamparska, Monika Wiłkość, Anita Markowska,
Ilona Laskowska-Levy, Marek Wróbel, Bogdan Małkowski

Fluencja słowna w badaniach techniką PET w warunkach przedłużonej aktywizacji poznawczej z zastosowaniem znacznika 18F-fluorodeoksyglukozy (FDG)

Verbal fluency in research conducted with PET technique under conditions of extended cognitive activation with the use of 18F-fluorodeoxyglucose (FDG) tracer

Introduction. Functional neuroimaging of the brain is a widely used method to study cognitive functions. Aim. The aim of this study was to compare the activity of the brain during performance of the tasks of phonemic and semantic fluency with the paced-overt technique in terms of prolonged activation of the brain. Methods. The study included 17 patients aged 20–40 years who were treated in the past for Hodgkin’s lymphoma, now in remission. Due to the type of task, the subjects were divided into two groups. Nine people performed the phonemic fluency task, and eight semantic. Due to the disease, all subjects were subject to neuropsychological diagnosis. The diagnosis of any cognitive impairment was an exclusion criterion. Neuroimaging was performed using PET technique with 18F-fluorodeoxyglucose (FDG) tracer. Results. Performance of a verbal fluency test, regardless of the version of the task, was associated with greater activity of the left hemisphere of the brain. The most involved areas compared with other areas of key importance for the performance of verbal fluency tasks were frontal lobes. An increased activity of parietal structures was also shown. Conclusions. The study did not reveal differences in brain activity depending on the type of task. Performing the test in both phonemic and semantic form for a long time, in terms of increased cognitive control resulting from the test procedure, could result in significant advantage of prefrontal lobe activity in both types of tasks and made it impossible to observe the processes specific to each of them.

ISSN 0033-2674 (PRINT)

ISSN 2391-5854 (ONLINE)

Psychiatria Polska
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