Online First Nr83

Psychiatr. Pol. ONLINE FIRST Nr 83: 1–11

Published ahead of print 27 November 2017

DOI: https://doi.org/10.12740/PP/OnlineFirst/80710

Błażej Misiak, Przemysław Bieńkowski, Jerzy Samochowiec

FREE POLISH FULLTEXT:
Kariprazyna – nowy lek przeciwpsychotyczny i jego miejsce w leczeniu schizofrenii

FREE ENGLISH FULLTEXT:
Cariprazine – a novel antipsychotic drug and its place in the treatment of schizophrenia

Summary
Although the development of second-generation antipsychotics was a cornerstone in the treatment of schizophrenia, several unmet treatment needs in the field still exist. It is particularly important to note that available antipsychotics have limited efficacy in the treatment of negative symptoms and cognitive impairment. At this point, it should be noted that primary negative symptoms, i.e., those that are not due to depression, extrapyramidal symptoms or psychotic withdrawal, might affect even one-fourth of patients with schizophrenia and are associated with poor clinical and functional outcomes. Cariprazine, is an emerging antipsychotic drug, D3/D2 receptor partial agonist, with affinity to several serotonin receptors. In this article, we provide an overview of pharmacokinetic and pharmacodynamic properties of cariprazine, showing its unique receptor profile. Next, we discuss results of double-blind, placebo-controlled, randomized clinical trials and post hoc analyses of cariprazine that have been published to date. These studies have provided evidence for efficacy of cariprazine in the treatment of schizophrenia exacerbations compared to placebo, with safety and good tolerability. In addition, one clinical trial published to date revealed superior efficacy of cariprazine compared to risperidone in the treatment of predominant negative symptoms that had been also associated with concomitant improvement of functional performance. Overall, current evidence in the field supports the use of cariprazine in exacerbation of schizophrenia and suggests promising efficacy in the treatment of predominant negative symptoms.



ISSN 0033-2674 (PRINT)

ISSN 2391-5854 (ONLINE)


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