Aim. The aim of this study was to analyse the level of compliance measured by patients, their families and psychiatrists. Method. 2009 patients who suffered from schizophrenia, 1791 members of their families and 203 psychiatrists were studied. They answered a questionnaire about the level of compliance and the factors which influence it. Results. The level of compliance in schizophrenia was evaluated by psychiatrists as 48%, families - 73% and patients - 85%. The psychiatrists assessed that 60% of the schizophrenic patients did not have the sense of illness. 11% of the patients said that they have no benefits from pharmacotherapy. Conclusions. The level of compliance is the least in doctor's evaluation. The patients evaluation of the level of compliance was the biggest. The level of compliance was related to patients' insight, negative attitude to pharmacotherapy, cognitive deficits. Women were more cooperative with medication than men.