Aim. The study was undertaken to investigate possible influence of alcoholism on the course and psychopathology of schizophrenia. Method. A representative sample of 61 subjects was selected from schizophrenic patients with a history of alcohol dependence (dual diagnosis) registered in the period of 1997-2000. They were compared with 60 control patients with a single diagnosis of schizophrenia. In two groups, with the interview and clinical scales, the onset, course and psych opathology of schizophrenia were assessed. Results. Male patients with schizophrenia and alcohol dependence had a later mean age at onset of mental illness, women - a higher rate of alcohol abuse in the family compared to the control groups. In men with dual diagnosis, the negative symptoms were less prominent. Women with schizophrenia and alcohol dependence reported more depressive symptomatology.