Background. We analyzed metabolic profile of patients with cognitive dysfunctions by means of levels of lipoproteins, glycaemia and hypertension. Research design and methods. In naturalistic, open manner, we studied 100 persons -44 without cognitive dysfunctions, 17 with MCI and 39 with dementia. Patients were grouped according to ICD-10, NIA/AA, McKhann's criteria of cognitive impairment and STMS cutoff levels. Results. We found correlations between HDL cholesterol (p=0.036, OR=1.061, <0.99; 1.13>), hyperglycaemia (p=0.008, OR=0.97, <0.95; 0.99>), metabolic syndrome (p=0.03; OR=0.34; <0.12; 0.91>) with age (p=0.001; OR=0.9; <0.84; 0.95>) and dementia. We confirmed also correlations of glucose levels with CT changes (p=0.01, OR=0.97, <0.95; 0.99>), and age (r=-0.47, p=0.000001), fasting glucose (r=-0.33, p=0.0024), HDL levels (r=0.32; p=0.05) with STMS results. Conclusions. Metabolic-cognitive syndrome seems to be a part of pathogenesis of dementia.