Introduction. Psychodynamic psychopharmacology offers possibility of implementation of psychodynamic thinking and interpretations in the process of pharmacotherapy of mental disorders. It can be helpful in improving results of treatment and solving difficulties in it's course. Method. The case report of a female patient after psychotic episode is presented. During the treatment with quetiapine the patient presented complains about adverse effects like weight gain and somnolence. These symptoms (at least partially) resulted from her emotional problems and changed after psychodynamic interpretation. After stopping the medication the patient's reactions to stress and process of separation from her mother changed dramatically. It was probably due to the discontinuation of medication. Results. In some cases adverse events of medication have not only biological but also emotional roots. if properly recognized they can be interpreted and changed by psychological tools. Conclusions. Psychodynamic psychopharmacology can be useful in deeper understanding and solving problems in the process of pharmacotherapy of mental disorders.