The analysis of the polymorphic variations of the dopamine gen transporter (DAT 1) and the serotonin transporter (5HTT_LPR) in patients with Alcohol Dependence Syndrome with inclusion of the phenotypic feature of sweet liking preference
1
Pomorska Akademia Medyczna
2
Pomorski Uniwersytet Medyczny, Katedra i Klinika Psychiatrii
3
Instytut Psychiatrii i Neurologii
Zakład farmakologii
4
Instytut Psychologii, Zakład Psychologii Klinicznej i Psychoprofilaktyki, Uniwersytet Szczecinski
5
Pomorski Uniwersytet Medyczny
Katedra i Klinika psychiatrii
Submission date: 2013-06-25
Final revision date: 2013-10-29
Acceptance date: 2013-11-24
Publication date: 2014-02-20
Corresponding author
Jerzy Samochowiec
Pomorski Uniwersytet Medyczny Katedra i Klinika psychiatrii, Broniewskiego 26, 71-460 Szczecin, Polska
Pomorski Uniwersytet Medyczny Katedra i Klinika psychiatrii, Broniewskiego 26, 71-460 Szczecin, Polska
Psychiatr Pol 2014;48(1):89-103
KEYWORDS
TOPICS
ABSTRACT
Objectives:
The purpose of this study was to determine the relationship between sweet-liking phenotype and the variation of the gene sequence of the dopaminergic and serotonergic system.
Methods:
The study recruited 100 probands. The participants were interviewed for addiction (SSAGA) and assessed with the questionnaires: MMSE, Beck Depression Inventory and Hamilton Anxiety, Snaith-Hamilton Pleasure Scale. The taste was analyzed with tests to assess sensitivity to sweet taste and also smell tests were performed. Patients preferring the highest glucose volumes were called sweet likers. Statistical analyses were performed (SPSS). Statistical analyses were performed (SPSS).
Results:
A genetically significant association between the presence of 9/10 DAT1 VNTR genotype and a sweet-liking phenotype in probands was determined.
Conclusions:
Links between sweet liking phenotype and polymorphic variant of DAT1 gene were determined. The presence of DAT1 9/10 genotype increased three fold time sweet liking phenotype (p=0,015, odds ratio-3,00), the presence of DAT1 10/10 decreased two fold time the chance being sweet liker (p=0,051, odds ratio-0,43). Genotype 10/10 was significantly more common among sweet dislikers 10/10 (68,18% vs 47,92%) i 9/9 (6,82% vs 2,08%).
The purpose of this study was to determine the relationship between sweet-liking phenotype and the variation of the gene sequence of the dopaminergic and serotonergic system.
Methods:
The study recruited 100 probands. The participants were interviewed for addiction (SSAGA) and assessed with the questionnaires: MMSE, Beck Depression Inventory and Hamilton Anxiety, Snaith-Hamilton Pleasure Scale. The taste was analyzed with tests to assess sensitivity to sweet taste and also smell tests were performed. Patients preferring the highest glucose volumes were called sweet likers. Statistical analyses were performed (SPSS). Statistical analyses were performed (SPSS).
Results:
A genetically significant association between the presence of 9/10 DAT1 VNTR genotype and a sweet-liking phenotype in probands was determined.
Conclusions:
Links between sweet liking phenotype and polymorphic variant of DAT1 gene were determined. The presence of DAT1 9/10 genotype increased three fold time sweet liking phenotype (p=0,015, odds ratio-3,00), the presence of DAT1 10/10 decreased two fold time the chance being sweet liker (p=0,051, odds ratio-0,43). Genotype 10/10 was significantly more common among sweet dislikers 10/10 (68,18% vs 47,92%) i 9/9 (6,82% vs 2,08%).
| eISSN: | 2391-5854 |
| ISSN: | 0033-2674 |
Project no. RCN/SN/0610/2021/1 implemented from 2022 to 2024
Total value of the project: PLN 490 000
Amount funded by the MEiN: PLN 100 000
Aims of the project: Publication in Open Access mode on the Internet of English and Polish language versions of 12 consecutive issues of the journal Psychiatria Polska (years 2022-2024). Modernization and redesign of the journal’s website. Financing of the Editorial System. Copy editing and proofreading of journal issues. Counteracting scientific misinformation. Submission of electronic versions of the journal to the National Digital Library Polona and the Digital Library of Scientific Publications Academica.
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