Autism spectrum disorder (ASD) as a serious neurodevelopmental condition requires intensive and comprehensive interventions, particularly interventions found to be effective through rigorous research. The National Professional Development Center on Autism Spectrum Disorders (NPDC) was formed in the USAin order to conduct a comprehensive review of ASD-related evidence-based practices (EBPs) and to create amodelof implementing such practices for children, adolescents and young adults (from preschool to high school education level). The NPDC final review, being the most comprehensive to date (the initial search included 29,105 articles) identified 27 ASD-focused EBPs. In addition to the resulting matrix of the autism-related EBPs, and the e-learning moduleson the identified interventions, the NPDC model includes as well the Autism Program Environment Rating Scale (APERS) for external evaluation and self-assessment, goal attainment scaling (GAS) and coaching program manual. To date, the model has been implemented in 12 states in the USAand is being introduced in several other countries including Australia, Sweden, Saudi Arabia, and Poland. The purpose of this article is to present the NPDC model and its components, along with the relevant research.