_7_21
Psychiatr. Pol. 2017; 51(1): 7–21DOI: https://doi.org/10.12740/PP/64581
Marek Jarema, Przemysław Bieńkowski, Janusz Heitzman,
Tadeusz Parnowski, Janusz Rybakowski
FREE POLISH FULLTEXT:
Palmitynian paliperidonu: skuteczność, bezpieczeństwo stosowania i miejsce w leczeniu schizofrenii
FREE ENGLISH FULLTEXT:
Paliperidone palmitate: effectiveness, safety, and the use for treatment of schizophrenia
Summary
The aim of the study was to summarize the efficacy and tolerability of paliperidone palmitate, an atypical long-acting antipsychotic drug. Paliperidone is a 9-hydroxy metabolite of risperidone with a slightly different receptor profile and significantly different pharmacokinetic profile. After the short review of its pharmacological properties, the efficacy of the drug in comparison to placebo or to an active comparator was described. The studies revealed the effectiveness of paliperidone palmitate in the treatment of psychotic symptoms, mainly schizophrenia. The drug proved to be efficacious in both acute psychotic symptoms treatment and long-term treatment. Its efficacy in patients with schizophrenia was similar and sometimes even better than the efficacy of other long-acting drugs, such as risperidone or olanzapine. In the pharmacoeconomic studies, paliperidone proved to be cost-effective in comparison to risperidone or olanzapine. The review of the literature also underlined that paliperidone palmitate is well tolerated, compared with placebo. Frequency and severity of side-effects such as extrapyramidal symptoms, hyperprolactinemia and weight gain, was similar or less than those found in treatment with other atypical antipsychotics, including long-acting ones.
ISSN 0033-2674 (PRINT)
ISSN 2391-5854 (ONLINE)
Psychiatria Polska
is an Open Access journal:
Creative Commons: CC-BY
SHERPA RoMEO: Blue
is an Open Access journal:
Creative Commons: CC-BY
SHERPA RoMEO: Blue

Zadanie finansowane
w ramach umowy
nr 739/P-DUN/2018
ze środków MNiSW
przeznaczonych
na działalność
upowszechniającą naukę
KRW PTP dziękuje
firmie PPL – Koral – J.Koral sp.j.
za wsparcie finansowe
udzielone w 2020 roku
Inne strony PTP:
Other PTP websites:
www.psychiatria.org.pl
www.psychiatriapsychoterapia.pl
www.archivespp.pl
www.psychoterapiaptp.pl
Psychiatria Polska
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CiteScore 2,4
(SJR 0,414; SNIP 0,707)
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